Publications | HaemaLogiX

Keywords: KappaMab | Clinical Trial | Kappa-type multiple myeloma

Asvadi, P., Cuddihy, A., Dunn, R.D., et al. (2015)

MDX‐1097 induces antibody‐dependent cellular cytotoxicity against kappa multiple myeloma cells and its activity is augmented by lenalidomide

British Journal Haematology, 169, 333-343

Keywords: KappaMab | In vitro | ADCC | Free light chains | Lenalidomide

Hutchinson, A.T., Alexova, R., Bockhorni, V., et al. (2011) Characterization of a unique conformational epitope on free immunoglobulin kappa light chains that is recognized by an antibody with therapeutic potential.

Molecular Immunology 48, 1245-1252

Keywords: KappaMab | K-1-21 or mKap | Immunoglobulin light chain | Epitope

Hutchinson, A.T., Ramsland, P.A., Jones, D.R., et al. (2010)

Free Ig light chains interact with sphingomyelin and are found on the surface of myeloma plasma cells in an aggregated form Journal of Immunology 185(7): 4179-4188

Wong, M., Asvadi, P., Dunn, R., (2009)

MDX-1097 binds specifically to kappa myeloma cells and anti-tumour activity is mediated by multiple effector cells

Blood (ASH Annual Meeting Abstracts), 114 (22): Abstract 1846

Keywords: KappaMab | In vitro | K-1-21 or mKap

Boux, H.A., Raison, R.L., Walker, K.Z., et al. (2006)

A tumor-associated antigen specific for human kappa myeloma cells

Journal of Experimental Medicine, 158(5): 1769-74

Keywords: In vitro | K-1-21 or mKap

Dunn, R.D., Weston, K.M., Longhurst, T.J., et al., (1996)

Antigen binding and cytotoxic properties of a recombinant immunotoxin incorporating the lytic peptide, melittin Immunotechnology, 2: 229-40

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Keywords: K-1-21 or mKap

Poster Presentations

Kalff,A., Shortt, J., Yuen, F., et al. (2019)

A sequential cohort study comparing KappaMab alone to KappaMab, lenalidomide and low dose dexamethasone in kappa-restricted relapsed refractory (RR) multiple myeloma (AMaRC 01-16)

HemaSphere, 3(S1): 633-34

Keywords: KappaMab | Clinical Trial | Kappa-type multiple myeloma | Lenalidomide

Gowrishankar, K., Dunn, R., Gottlieb, D., and Micklethwaite, K. (2018)

CAR T-cells targeting the kappa myeloma antigen for the treatment of multiple myeloma

Abstract 3572, AACR 2018 annual meeting; April 14-18; Chicago, IL.

Keywords: CAR T cells | Kappa-type multiple myeloma

Spencer, A., Augustson, B., Mollee, P, et al. (2013)

Phase 2a, open-label, multi-dose study of the anti-kappa monoclonal antibody, MDX-1097, in relapsed kappa-chain restricted multiple myeloma with stable measurable disease

European Haematology Association Meeting, May 2013

Keywords: KappaMab / MDX-1097 | Clinical Trial | Kappa-type multiple myeloma KMA

Asvadi, P., Jennings, C., Jiang, V., et al. (2013)

Identification and characterization of lambda myeloma antigen, LMA, as a therapeutic target in lambda type multiple myeloma

European Haematology Association Meeting, 2013

Keywords: Lambda-type multiple myeloma / LMA

Cuddihy, A.R., Khong, T., Dunn, R., et al. (2012)

The anti-kappa monoclonal antibody MDX-1097 cooperates with lenalidomide to enhance antibody-dependent cell cytotoxicity of multiple myeloma cells

Abstract 2522, AACR Annual Meeting, March 31-April 4; Chicago, IL.

Keywords: KappaMab / MDX-1097 | In vitro | ADCC / Apoptosis | Lenalidomide

Cuddihy, A.R., Khong, T., Dunn, R., et al. (2012)

The anti-kappa monoclonal antibody MDX-1097 cooperates with immunomodulatory drugs to enhance antibody-dependent cell cytotoxicity of multiple myeloma cells

Blood, 120(21): 4012

Keywords: KappaMab / MDX-1097 | In vitro | ADCC / Apoptosis

Cuddihy, A. R., Khong, T, Dunn, R. (2012)

The anti-KMA monoclonal antibody MDX-1097 cooperates with IMiDs and HDACi to enhance antibody-dependent cell cytotoxicity of multiple myeloma cells

European Haematology Association Meeting, 2012

Spencer, A., Walker, P., Asvadi, P., et al. (2010)

A phase I study of the anti-kappa monoclonal antibody, MDX-1097, in previously treated multiple myeloma patients

Journal of Clinical Oncology 28(15_suppl).

Keywords: KappaMab / MDX-1097 | Clinical Trial | Kappa-type multiple myeloma / KMA

Wong, M., Asvadi, P., Dunn, R., et al. (2009)

MDX-1097 Binds specifically to kappa myeloma cells and anti-tumour activity is mediated by multiple effector cells

Blood, 114(22): 1846

Keywords: KappaMab / MDX-1097 | In vitro

Jones, D.R. Asvadi, P., Raison, R.L., et al. (2007)

Expression of the kappa myeloma antigen on the cell surface of bone marrow aspirates from Waldenstrom’s Macroglobulinemia patients. Haematologica, 92(s2): PO-1207

Keywords: KappaMab / MDX-1097 | In vitro | Waldenstrom's macroglobulinemia

Alexova, R., Hutchinson, A., Jones, D.R., et al. (2007)

Characterisation of a novel conformational epitope on human free kappa light chains defined by a monoclonal antibody with therapeutic potential for multiple myeloma.

Australian and New Zealand Society for Immunology meeting Sydney Australia, 2007.

Keywords: Free light chains | K-1-21 or mKap | Epitope

Raison, R.L., Jones, D.R., Asvadi, P., et al. (2005)

A chimeric monoclonal antibody specific for kappa multiple myeloma plasma cells mediates ADCC of tumor cells

Haematologica, 2005; 90(s1)

Keywords: K-1-21 or mKap | In vivo model

Asvadi, P., Jones, D.R., Dunn, R., et al. (2004)

A monoclonal antibody specific for free human kappa light chains induces apoptosis of multiple myeloma cells and exhibits anti-tumor activity in vivo

Blood. 104(11): 2416

Keywords: K-1-21 or mKap | In vivo model | ADCC / Apoptosis

Goodnow, C.C., Raison, R.L., (1985)

Structural analysis of the myeloma-associated membrane antigen KMA

The Journal Immunology, 135(2): 1276-1280

Keywords: KappaMab | K-1-21 or mKap

Walker, K.Z., Boux, H.A., Hayden, G.E., et al. (1985)

A monoclonal antibody with selectivity for human kappa myeloma and lymphoma cells which has a potential as a therapeutic agent

In: Microenvironments in the Lymphoid System. Edited by G.G.B Klaus, Plenum Publishing Corporation

Keywords: Free light chains | K-1-21 or mKap

Raison, R.L. and Boux, H.A. (1985)

Conformation dependence of a monoclonal antibody defined epitope on free human kappa chains

Molecular Immunology, 22(12): 1393-98

Keywords: K-1-21 or mKap | Epitope

Walker, K.Z., Hayden, G.E., Goodnow, C.C., et al. (1985)

Co-expression of an epitope on human free κ-light chains and on a cytoplasmic component in activated T cells

The Journal Immunology, 134(2): 1059-64

Keywords: In vitro | K-1-21 or mKap

Boux, H.A., Raison, R.L., Walker, K.Z., et al. (1984)

The surface expression of a tumor-associated antigen on human kappa myeloma cells

Eur. J Immunol., 14: 216-222