Spencer, A., Walker, P., Asvadi, P. et al. (2019)
A preliminary study of the anti-κ myeloma antigen monoclonal antibody KappaMab (MDX-1097) in pretreated patients with κ-restricted multiple myeloma
Blood Cancer Journal 9, Article no. 58
Keywords: KappaMab | Clinical Trial | Kappa-type multiple myeloma
Asvadi, P., Cuddihy, A., Dunn, R.D., et al. (2015)
MDX‐1097 induces antibody‐dependent cellular cytotoxicity against kappa multiple myeloma cells and its activity is augmented by lenalidomide
British Journal Haematology, 169, 333-343
Keywords: KappaMab | In vitro | ADCC | Free light chains | Lenalidomide
Hutchinson, A.T., Alexova, R., Bockhorni, V., et al. (2011) Characterization of a unique conformational epitope on free immunoglobulin kappa light chains that is recognized by an antibody with therapeutic potential.
Molecular Immunology 48, 1245-1252
Keywords: KappaMab | K-1-21 or mKap | Immunoglobulin light chain | Epitope
Hutchinson, A.T., Ramsland, P.A., Jones, D.R., et al. (2010)
Free Ig light chains interact with sphingomyelin and are found on the surface of myeloma plasma cells in an aggregated form Journal of Immunology 185(7): 4179-4188
Keywords: KappaMab | In vitro | Free light chains | K-1-21 or mKap | Immunoglobulin light chain | Epitope
Wong, M., Asvadi, P., Dunn, R., (2009)
MDX-1097 binds specifically to kappa myeloma cells and anti-tumour activity is mediated by multiple effector cells
Blood (ASH Annual Meeting Abstracts), 114 (22): Abstract 1846
Keywords: KappaMab | In vitro | K-1-21 or mKap
Boux, H.A., Raison, R.L., Walker, K.Z., et al. (2006)
A tumor-associated antigen specific for human kappa myeloma cells
Journal of Experimental Medicine, 158(5): 1769-74
Keywords: In vitro | K-1-21 or mKap
Dunn, R.D., Weston, K.M., Longhurst, T.J., et al., (1996)
Antigen binding and cytotoxic properties of a recombinant immunotoxin incorporating the lytic peptide, melittin Immunotechnology, 2: 229-40
Keywords: K-1-21 or mKap
Boux, H.A., Raison, R.L., Walker, K.Z., et al. (1984)
The surface expression of a tumor-associated antigen on human kappa myeloma cells
Eur. J Immunol., 14: 216-222
Keywords: In vitro | Free light chains | K-1-21 or mKap | Epitope
Boux, H.A., Raison, R.L., Walker, K.Z., et al. (1983)
A tumour-associated antigen specific for human kappa myeloma cells
J Exp Med., 158(5): 1769-74
Keywords: In vitro | Free light chains | K-1-21 or mKap | Epitope
Poster Presentations
Sartor, M., Gottlieb, DJ., and Dunn, R. (2022)
Novel Antigens LMA and KMA are Expressed on Malignant Bone Marrow Plasma Cells from Patients with Relapsed Refractory Multiple Myeloma and Plasma Cell Dyscrasias. Blood (2022) 140 (Supplement 1): 4211–4212.
View summary presentation video
Keywords: KappaMab | LambdaMab | Plasma Cell Dyscrasias | Multiple Myeloma | KMA | LMA
Sartor, M., Hu, D., Lemarchand, T.X., et al. (2021)
A Novel B Cell Antigen Designated Lambda Myeloma Antigen (LMA) Has Been Identified Using Two Fully Human Monoclonal Antibodies (Mabs) That Bind to Similar Epitopes on Plasma Cells from Patients with Plasma Cell Dyscrasias.
Blood (2021) 138(Supplement 1):1595.
View summary presentation video
Keywords: KappaMab | LambdaMab | Plasma Cell Dyscrasias | 10B3 | 7F11
Kalff, A., Shortt, J., Yuen, F., et al. (2019)
A sequential cohort study comparing KappaMab alone to KappaMab, lenalidomide and low dose dexamethasone in kappa-restricted relapsed refractory (RR) multiple myeloma (AMaRC 01-16).
Blood (2019) 134 (Supplement 1): 3144.
Keywords: KappaMab | Clinical Trial | Kappa-type multiple myeloma | Lenalidomide
Gowrishankar, K., Dunn, R., Gottlieb, D., and Micklethwaite, K. (2018)
CAR T-cells targeting the kappa myeloma antigen for the treatment of multiple myeloma
Cancer Res (2018) 78 (13_Supplement):3572
Keywords: CAR T cells | Kappa-type multiple myeloma
Dunn, R., Spencer, A., Augustson B., et al. (2013)
Phase 2a, open-label, multi-dose study of the anti-kappa monoclonal antibody, MDX-1097, in relapsed kappa-chain restricted multiple myeloma with stable measurable disease
Haematologica, 2013; 98(s1):324. Abstract no. P776
Keywords: KappaMab / MDX-1097 | Clinical Trial | Kappa-type multiple myeloma KMA
Asvadi, P., Jennings, C., Jiang, V., et al. (2013)
Identification and characterization of lambda myeloma antigen, LMA, as a therapeutic target in lambda type multiple myeloma
Haematologica, 2013; 98(s1):316. Abstract no. P756.
Keywords: Lambda-type multiple myeloma / LMA
Cuddihy, A.R., Khong, T., Dunn, R., et al. (2012)
The anti-kappa monoclonal antibody MDX-1097 cooperates with lenalidomide to enhance antibody-dependent cell cytotoxicity of multiple myeloma cells
Cancer Res (2012) 72 (8_Supplement): 2522.
Keywords: KappaMab / MDX-1097 | In vitro | ADCC / Apoptosis | Lenalidomide
Cuddihy, A.R., Khong, T., Dunn, R., et al. (2012)
The anti-kappa monoclonal antibody MDX-1097 synergizes with immunomodulatory drugs to enhance antibody-dependent cell cytotoxicity of multiple myeloma cells
Blood (2012), 120(21): 4012
Keywords: KappaMab / MDX-1097 | In vitro | ADCC / Apoptosis
Cuddihy, A. R., Khong, T, Dunn, R. (2012)
The anti-KMA monoclonal antibody MDX-1097 cooperates with IMiDs and HDACi to enhance antibody-dependent cell cytotoxicity of multiple myeloma cells
14th International Myeloma Workshop Meeting (Dec 2012):P-281. Kyoto, Japan.
Keywords: KappaMab | MDX-1097 | ADCC
Spencer, A., Walker, P., Asvadi, P., et al. (2010)
A phase I study of the anti-kappa monoclonal antibody, MDX-1097, in previously treated multiple myeloma patients
Journal of Clinical Oncology 28(15_suppl).
Keywords: KappaMab / MDX-1097 | Clinical Trial | Kappa-type multiple myeloma / KMA
Wong, M., Asvadi, P., Dunn, R., et al. (2009)
MDX-1097 Binds specifically to kappa myeloma cells and anti-tumour activity is mediated by multiple effector cells
Blood, 114(22): 1846
Keywords: KappaMab / MDX-1097 | In vitro
Jones, D.R. Asvadi, P., Raison, R.L., et al. (2007)
Expression of the kappa myeloma antigen on the cell surface of bone marrow aspirates from Waldenstrom’s Macroglobulinemia patients. Haematologica, 92(s2): PO-1207
Keywords: KappaMab / MDX-1097 | In vitro | Waldenstrom's macroglobulinemia
Alexova, R., Hutchinson, A., Jones, D.R., et al. (2007)
Characterisation of a novel conformational epitope on human free kappa light chains defined by a monoclonal antibody with therapeutic potential for multiple myeloma.
Australian and New Zealand Society for Immunology meeting Sydney Australia, 2007.
Keywords: Free light chains | K-1-21 or mKap | Epitope
Raison, R.L., Jones, D.R., Asvadi, P., et al. (2005)
A chimeric monoclonal antibody specific for kappa multiple myeloma plasma cells mediates ADCC of tumor cells
Haematologica, 2005; 90(s1)
Keywords: K-1-21 or mKap | In vivo model
Asvadi, P., Jones, D.R., Dunn, R., et al. (2004)
A monoclonal antibody specific for free human kappa light chains induces apoptosis of multiple myeloma cells and exhibits anti-tumor activity in vivo
Blood. 104(11): 2416
Keywords: K-1-21 or mKap | In vivo model | ADCC / Apoptosis
Goodnow, C.C., Raison, R.L., (1985)
Structural analysis of the myeloma-associated membrane antigen KMA
The Journal Immunology, 135(2): 1276-1280
Keywords: KappaMab | K-1-21 or mKap
Walker, K.Z., Boux, H.A., Hayden, G.E., et al. (1985)
A monoclonal antibody with selectivity for human kappa myeloma and lymphoma cells which has a potential as a therapeutic agent
In: Microenvironments in the Lymphoid System. Edited by G.G.B Klaus, Plenum Publishing Corporation
Keywords: Free light chains | K-1-21 or mKap
Raison, R.L. and Boux, H.A. (1985)
Conformation dependence of a monoclonal antibody defined epitope on free human kappa chains
Molecular Immunology, 22(12): 1393-98
Keywords: K-1-21 or mKap | Epitope
Walker, K.Z., Hayden, G.E., Goodnow, C.C., et al. (1985)
Co-expression of an epitope on human free κ-light chains and on a cytoplasmic component in activated T cells
The Journal Immunology, 134(2): 1059-64
Keywords: In vitro | K-1-21 or mKap
Published Manuscripts