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Spencer, A., Walker, P., Asvadi, P. et al. (2019) 

A preliminary study of the anti-κ myeloma antigen monoclonal antibody KappaMab (MDX-1097) in pretreated patients with κ-restricted multiple myeloma

Blood Cancer Journal 9, Article no. 58 

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Keywords: KappaMab  |  Clinical Trial  |  Kappa-type multiple myeloma

Asvadi, P., Cuddihy, A., Dunn, R.D., et al. (2015) 

MDX‐1097 induces antibody‐dependent cellular cytotoxicity against kappa multiple myeloma cells and its activity is augmented by lenalidomide 

British Journal Haematology, 169, 333-343

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Keywords: KappaMab  |  In vitro  |  ADCC  |  Free light chains  |  Lenalidomide

Hutchinson, A.T., Alexova, R., Bockhorni, V., et al. (2011) Characterization of a unique conformational epitope on free immunoglobulin kappa light chains that is recognized by an antibody with therapeutic potential.

Molecular Immunology 48, 1245-1252

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Keywords:  KappaMab  |  K-1-21 or mKap  |  Immunoglobulin light chain  |  Epitope  

Hutchinson, A.T., Ramsland, P.A., Jones, D.R., et al. (2010)

Free Ig light chains interact with sphingomyelin and are found on the surface of myeloma plasma cells in an aggregated form Journal of Immunology 185(7): 4179-4188

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Keywords:   KappaMab  |  In vitro  |  Free light chains  |  K-1-21 or mKap  |  Immunoglobulin light chain  |  Epitope 

Wong, M., Asvadi, P., Dunn, R., (2009)

MDX-1097 binds specifically to kappa myeloma cells and anti-tumour activity is mediated by multiple effector cells

Blood (ASH Annual Meeting Abstracts), 114 (22): Abstract 1846

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Keywords:   KappaMab  |  In vitro  |  K-1-21 or mKap  

Boux, H.A., Raison, R.L., Walker, K.Z., et al. (2006)

A tumor-associated antigen specific for human kappa myeloma cells 

Journal of Experimental Medicine, 158(5): 1769-74

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Keywords:   In vitro  |  K-1-21 or mKap  

Dunn, R.D., Weston, K.M., Longhurst, T.J., et al., (1996)

Antigen binding and cytotoxic properties of a recombinant immunotoxin incorporating the lytic peptide, melittin Immunotechnology, 2: 229-40

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Keywords:   K-1-21 or mKap  

Boux, H.A., Raison, R.L., Walker, K.Z., et al. (1984)

The surface expression of a tumor-associated antigen on human kappa myeloma cells

Eur. J Immunol., 14: 216-222

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Keywords:   In vitro  |  Free light chains  |  K-1-21 or mKap  |  Epitope

Boux, H.A., Raison, R.L., Walker, K.Z., et al. (1983)

A tumour-associated antigen specific for human kappa myeloma cells

J Exp Med., 158(5): 1769-74

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Keywords:   In vitro  |  Free light chains  |  K-1-21 or mKap  |  Epitope

Poster Presentations

Sartor, M., Gottlieb, DJ., and Dunn, R. (2022)

Novel Antigens LMA and KMA are Expressed on Malignant Bone Marrow Plasma Cells from Patients with Relapsed Refractory Multiple Myeloma and Plasma Cell Dyscrasias. Blood (2022) 140 (Supplement 1): 4211–4212.

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Keywords: KappaMab | LambdaMab | Plasma Cell Dyscrasias | Multiple Myeloma | KMA | LMA

Sartor, M., Hu, D., Lemarchand, T.X., et al. (2021)

A Novel B Cell Antigen Designated Lambda Myeloma Antigen (LMA) Has Been Identified Using Two Fully Human Monoclonal Antibodies (Mabs) That Bind to Similar Epitopes on Plasma Cells from Patients with Plasma Cell Dyscrasias.

Blood (2021) 138(Supplement 1):1595.

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Keywords: KappaMab | LambdaMab | Plasma Cell Dyscrasias | 10B3 | 7F11

Kalff, A., Shortt, J., Yuen, F., et al. (2019)

A sequential cohort study comparing KappaMab alone to KappaMab, lenalidomide and low dose dexamethasone in kappa-restricted relapsed refractory (RR) multiple myeloma (AMaRC 01-16).

Blood (2019) 134 (Supplement 1): 3144.

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Keywords: KappaMab  |  Clinical Trial  |  Kappa-type multiple myeloma  |  Lenalidomide

Gowrishankar, K., Dunn, R., Gottlieb, D., and Micklethwaite, K. (2018)

CAR T-cells targeting the kappa myeloma antigen for the treatment of multiple myeloma

Cancer Res (2018) 78 (13_Supplement):3572

 

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Keywords:   CAR T cells  |  Kappa-type multiple myeloma

Dunn, R., Spencer, A., Augustson B., et al. (2013)

Phase 2a, open-label, multi-dose study of the anti-kappa monoclonal antibody, MDX-1097, in relapsed kappa-chain restricted multiple myeloma with stable measurable disease

Haematologica, 2013; 98(s1):324. Abstract no. P776

 

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Keywords:   KappaMab / MDX-1097  |  Clinical Trial  |  Kappa-type multiple myeloma KMA

Asvadi, P., Jennings, C., Jiang, V., et al. (2013)

Identification and characterization of lambda myeloma antigen, LMA, as a therapeutic target in lambda type multiple myeloma

Haematologica, 2013; 98(s1):316. Abstract no. P756.

 

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Keywords:   Lambda-type multiple myeloma / LMA

Cuddihy, A.R., Khong, T., Dunn, R., et al. (2012)

The anti-kappa monoclonal antibody MDX-1097 cooperates with lenalidomide to enhance antibody-dependent cell cytotoxicity of multiple myeloma cells

Cancer Res (2012) 72 (8_Supplement): 2522. 

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Keywords:   KappaMab / MDX-1097  |  In vitro  |  ADCC / Apoptosis  |  Lenalidomide

Cuddihy, A.R., Khong, T., Dunn, R., et al. (2012)

The anti-kappa monoclonal antibody MDX-1097 synergizes with immunomodulatory drugs to enhance antibody-dependent cell cytotoxicity of multiple myeloma cells

Blood (2012), 120(21): 4012

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Keywords:   KappaMab / MDX-1097  |  In vitro  |  ADCC / Apoptosis

Cuddihy, A. R., Khong, T, Dunn, R. (2012)

The anti-KMA monoclonal antibody MDX-1097 cooperates with IMiDs and HDACi to enhance antibody-dependent cell cytotoxicity of multiple myeloma cells

14th International Myeloma Workshop Meeting (Dec 2012):P-281. Kyoto, Japan.

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Keywords: KappaMab | MDX-1097 | ADCC

Spencer, A., Walker, P., Asvadi, P., et al. (2010)

A phase I study of the anti-kappa monoclonal antibody, MDX-1097, in previously treated multiple myeloma patients

Journal of  Clinical Oncology 28(15_suppl).

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Keywords:   KappaMab / MDX-1097  |  Clinical Trial  |  Kappa-type multiple myeloma / KMA

Wong, M., Asvadi, P., Dunn, R., et al. (2009)

MDX-1097 Binds specifically to kappa myeloma cells and anti-tumour activity is mediated by multiple effector cells

Blood, 114(22): 1846

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Keywords:   KappaMab / MDX-1097  |  In vitro 

Jones, D.R. Asvadi, P., Raison, R.L., et al. (2007)

Expression of the kappa myeloma antigen on the cell surface of bone marrow aspirates from Waldenstrom’s Macroglobulinemia patients. Haematologica, 92(s2): PO-1207

 

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Keywords:   KappaMab / MDX-1097  |  In vitro  |  Waldenstrom's macroglobulinemia

Alexova, R., Hutchinson, A., Jones, D.R., et al. (2007)

Characterisation of a novel conformational epitope on human free kappa light chains defined by a monoclonal antibody with therapeutic potential for multiple myeloma.

Australian and New Zealand Society for Immunology meeting Sydney Australia, 2007.

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Keywords:   Free light chains  |  K-1-21 or mKap  |  Epitope

Raison, R.L., Jones, D.R., Asvadi, P., et al. (2005)

A chimeric monoclonal antibody specific for kappa multiple myeloma plasma cells mediates ADCC of tumor cells

Haematologica, 2005; 90(s1)

 

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Keywords:   K-1-21 or mKap  |  In vivo model

Asvadi, P., Jones, D.R., Dunn, R., et al. (2004)

A monoclonal antibody specific for free human kappa light chains induces apoptosis of multiple myeloma cells and exhibits anti-tumor activity in vivo

Blood. 104(11): 2416
 

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Keywords:   K-1-21 or mKap  |  In vivo model  |  ADCC / Apoptosis

Published Manuscripts
Poster Presentations

Goodnow, C.C., Raison, R.L., (1985)

Structural analysis of the myeloma-associated membrane antigen KMA

The Journal Immunology, 135(2): 1276-1280

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Keywords:   KappaMab  |  K-1-21 or mKap  

Walker, K.Z., Boux, H.A., Hayden, G.E., et al. (1985)

A monoclonal antibody with selectivity for human kappa myeloma and lymphoma cells which has a potential as a therapeutic agent

In: Microenvironments in the Lymphoid System. Edited by G.G.B Klaus, Plenum Publishing Corporation

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Keywords:   Free light chains  |  K-1-21 or mKap  

Raison, R.L. and Boux, H.A. (1985)

Conformation dependence of a monoclonal antibody defined epitope on free human kappa chains

Molecular Immunology, 22(12): 1393-98

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Keywords:   K-1-21 or mKap  |  Epitope

Walker, K.Z., Hayden, G.E., Goodnow, C.C., et al. (1985)

Co-expression of an epitope on human free κ-light chains and on a cytoplasmic component in activated T cells

The Journal Immunology, 134(2): 1059-64

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Keywords:   In vitro  |  K-1-21 or mKap  

Published Manuscripts

Publications

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